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Activation pathways (Classical, Lectin, Alternative) and clinical pathologies.
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Target virally infected cells and tumor cells lacking MHC Class I.
B cells internalize protein antigens, present them on MHC Class II to an activated CD4+ Helper T cell. The interaction between CD40 on the B cell and CD40L (CD154) on the T cell, combined with T-cell cytokines, drives clonal expansion, somatic hypermutation, and affinity maturation. 5. Immunoglobulins (Antibodies)
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